Endocrine Abstracts

Introduction: Besides of the neuroendocrine actions including the stimulatory effects on growth hormone, prolactin and adrenocorticotropin release, acylated ghrelin (AG) plays a role in the regulation of metabolic processes, resulting in the decrease of insulin secretion and increase of hepatic glucose release. Despite of many earlier studies, the mechanisms involved in AG secretion have not been established. The aim of study was to assess the influence of leptin on AG.<p ...

Obesity is considered as a state of chronic, systemic low-grade inflammation. Likely causes include infectious factors, leptin, cigarette smoking, low serum HDL-cholesterol and high serum triglycerides. No definitive confirmation on the causative factor is available so far.The aim of the study was to evaluate serum levels of C-reactive protein (hs-CRP, sensitivity 0,085 ng/L), IL-6, IL-10, TNF-α and its soluble type 2 receptor (sTNF-αR-2) in vi...

Background: Many patients with type 2 diabetes (T2D) are not reaching glycemic targets even by using different combinations of antidiabetic drugs, including insulin. On the other hand, intensified multidrug therapy is associated with increased risk of severe side effects and individualized selection of medication is essential. The aim of our study is to evaluate efficiency of personalized pharmacotherapy according to the genotype and phenotype of T2D patients.<p class="abs...